glc

Glucose

gln

Glutamine

GLP

Good laboratory practice

GMO

Genetically modified organism

GMP

Good manufacturing practice

HA

Hemagglutinin

HCD

High cell density

HCV

Hepatitis C virus

HFBR

Hollow fiber bioreactor

hpi

Hours post infection

HSV1

Herpes simplex virus 1

IAV

Influenza A virus

iBET

Instituto de Biologia Experimental e Tecnológica

ic

Icellis

IGF

Insulin-like growth factor

IND

Investigational new drug (application)

IL

Interleukin

lac

Lactate

MCB

Master cell bank

MEV

Mink enteritis virus

MHS

Multivalent heparan sulfate

MIR

Mid-infrared spectroscopy

MMR

Measles, mumps, rubella

mRNA

Messenger RNA

MSL

Master seed lot

µ-F

Microfiltration

MVA

Modified Vaccinia virus Ankara

N

Number of cell expansions for production

NIBSC

National Institute for Biological Standards and Control

NIR

Near-infrared spectroscopy

NMR

Nuclear magnetic resonance

NRC

National Research Council Canada

OSB

Orbital shaken bioreactor

PAT

Process analytical tools

PBBR

Packed bed bioreactor

PBS

Phosphate buffered saline

PCR

Polymerase chain reaction

PDGF

Platelet-derived growth factor

pDNA

Plasmid DNA

PFM

Protein free medium

pSTR

Perfusion STR

RB

Roller bottle

Rec

Recombinant

RNA

Ribonucleic acid

QMS

Quality management system

SARS

Severe acute respiratory syndrome

134

Bioprocessing of Viral Vaccines